|
TIME |
11-Dec-04 |
|
6:30 PM |
Welcome Reception and Registration |
|
|
|
|
TIME |
12-Dec-04 |
|
9:00 AM |
Welcome Notes |
Ratan Bhat |
|
9:15 AM |
PLENARY LECTURE: Genetic Dissection of the Etiologies
and Pathogeneses of Alzheimer’s and Parkinson’s Diseases
and Related Disorders |
John Hardy |
|
10:15 AM |
Coffee Break |
|
10:30 AM |
SESSION 1: Neurofibrillary
Degeneration |
CHAIR: Ratan Bhat |
|
Michal Novak |
Alzheimer Neurofibrillary Degeneration: Generation of a
Transgenic Rat Model |
|
11:00 AM |
Mary Savage |
Kinase Targets in Neurodegeneration and Dementia |
|
11:30 AM |
Ratan Bhat |
Role of GSK3 in Alzheimer´s Disease Pathophysiology |
|
12:00 PM |
Lunch |
|
1:30 PM |
SESSION 2: Amyloidosis |
CHAIR: John Hardy |
|
Linda Soderberg |
CLAC, a Novel Amyloid Associated Protein - Biochemical
and Immunohistochemical Studies |
|
2:00 PM |
Pascal Merchiers |
GPCR Modulators of Beta-amyloid Secretion |
|
2:30 PM |
Alan Snow |
Development of Exebryl-1 : A Disease Modifying Compound
that Causes a Marked Clearance of Brain Amyloid Plaque
Burden and Improved Memory in Transgenic Mouse Models of
Alzheimer's Disease |
|
3:00 PM |
Coffee Break |
|
3:15 PM |
Jason Ho |
Molecular Basis of Interactions Between Serum Amyloid P
and Multivalent Ligands |
|
3:45 PM |
Kina Hoglund |
Statin treatment and a disease-specific pattern of Beta-Amyloid
peptides in Alzheimer’s disease |
|
4:15 PM |
Judianne Davis |
Specific Expression of Human Amyloid ß-Protein Precursor
in Platelets of Transgenic Mice |
|
4:45 PM |
Bill Van Nostrand |
Lack of Apolipoprotein E Alters Aß Deposition and
Distribution in Transgenic Mice Expressing
Swedish/Dutch/Iowa Mutant Human Aßpp |
|
5:15 PM |
End Sessions |
|
|
|
|
|
TIME |
13-Dec-04 |
|
9:00 AM |
SESSION 3: Animal Models |
CHAIR: Karen Duff |
|
|
Karen Hsiao Ashe |
Plasticity and recovery of function in transgenic mice
with neurofibrillary pathology |
|
9:30 AM |
Li-Huei Tsai |
The Inducible p25 Transgenic Mouse as an Alzheimer's
Disease Model |
|
10:00 AM |
Karen Duff |
Aberrant Phosphorylation in Tauopathy and Amyloidosis |
|
10:30 AM |
Coffee Break |
|
10:45 AM |
SESSION 4: Chemical Approaches |
CHAIR: Robert Hudkins |
|
Laurent Meijer |
Pharmacological inhibitors of CDK5 and GSK-3 |
|
11:15 AM |
James McCarthy |
Design and Synthesis of BACE Inhibitors |
|
11:45 AM |
Varghese John |
Human b-secretase (BACE) and BACE inhibitors |
|
12:15 PM |
Robert Hudkins |
Targeting the Mixed Lineage Kinase Family for
Alzheimer’s |
|
12:45 PM |
Lunch |
|
2:00 PM |
SESSION 5:
Alzheimer´s Clinical Trials I |
CHAIR: Hans
Basun |
|
Denis Garceau |
Alzhemed - A New Promising Treatment of Alzheimer's
Disease |
|
2:30 PM |
Craig W. Ritchie |
MPACS and Alzheimer's Disease |
|
3:00 PM |
Hans Basun |
A perspective on Clinical Trials in Alzheimer's Disease |
|
3:30 PM |
Coffee Break |
|
3:45 PM |
SESSION 6: Diet and A-beta
Homeostasis |
CHAIR: Robert P. Friedland |
|
Dmitry Goldgaber |
Modulation Of Transthyretin By Pharmacological Agents |
|
4:15 PM |
Robert P. Friedland |
Transthyretin and Alzheimer's Disease |
|
4:45 PM |
End Sessions |
|
|
|
|
|
TIME |
14-Dec-04 |
|
9:00 AM |
PLENARY LECTURE:
Why and How to Inhibit
Alzheimer Neurofibrillary Degeneration? |
Khalid Iqbal |
|
10:00 AM |
Coffee Break |
|
10:30 AM |
SESSION 7: Alzheimer's Vaccine Update |
Dale Schenk |
|
11:30 AM |
Lunch |
|
End Sessions |
|
|
|
|
|
TIME |
15-Dec-04 |
|
8:30 AM |
SESSION 8: Novel Approaches |
Co-CHAIRS:
Ashley Bush and Richard Bowen |
|
William Klein |
Synaptic Targeting by Abeta Oligomers (ADDLs): A
Treatable Mechanism for Early AD Memory Loss? |
|
9:00 AM |
Ashley Bush |
Metallobiology and Drug Discovery in Alzheimer's disease |
|
9:30 AM |
Richard Bowen |
Anti-Gonadotropins as a Potential Therapry for
Alzheimer's Disease |
|
10:00 AM |
Tania Valdes-Gonzales |
A New Concept for the Treatment and Prevention of
Alzheimer's Disease |
|
10:30 AM |
Coffee Break |
|
10:45 AM |
SESSION 9: Neurofibrillary Degeneration II |
CHAIR:
Jesus Avila |
|
|
Peter Davies |
Mechanisms of Tau-Mediated Cell Death |
|
11:15 AM |
Michael L. Hutton |
Mouse Models of Tauopathy: Progress in Mechanism and
Therapy |
|
11:45 AM |
Jesus Avila |
Tau Phosphorylation and Assembly |
|
12:15 PM |
Lunch |
|
1:30 PM |
Ilho Ha |
P25/CDK5 Inhibitors to Reduce the Secretion of A-beta
from the p25-Overexpressing Cells |
|
2:00 PM |
SESSION 10: Biomarkers |
CHAIR: Lars
Lannfelt |
|
Rivka Ravid |
Biobanking and Brain Banking in Neurological and
Psychiatric Disorders |
|
2:30 PM |
Magnus Sjögren |
Clinical Biomarkers of Alzheimer's Disease - Current
Status and Needs |
|
3:00 PM |
Lars Lannfelt |
Soluble Abeta Protfibrils in the Pathogenesis of
Alzheimer's Disease |
|
3:30 PM |
Coffee Break |
|
3:45 PM |
SESSION 11: Treatment Strategies
and Disease Modifications in AD |
CHAIR:
Abraham Fisher |
|
Nibaldo C. Inestrosa |
Signal Transduction Pathways that Mediate Ab
Neurotoxicity |
|
4:15 PM |
Kevin M. Felsenstein |
Approaches Toward Disease Modification in Alzheimer's
Disease |
|
4:45 PM |
Abraham Fisher |
The Unique Therapeutic Potential of M1 Muscarinic
Agonists in Alzheimer's Disease and Cerebral Amyloid
Angiopathy |
|
5:15 PM |
End Sessions |
|
|
|
|
|
TIME |
16-Dec-04 |
|
9:00 AM |
SESSION 12: Chemical Approaches II |
CHAIR:
Stefan Berg |
|
Prasad V Chaturvedula |
Design and Synthesis of gamma-Secretase Inhibitors |
|
9:30 AM |
Ian Churcher |
Gamma Secretase Inhibitors: Efficacy versus Toxicity |
|
10:00 AM |
Conrad Kunick |
The Paullones - A Class of Dual GSK-3/CDK5 Inhibitors |
|
10:30 AM |
Coffee Break |
|
11:00 AM |
Ernest ter Haar |
Structure Based Drug Design in GSK3b |
|
11:30 AM |
Stefan Berg |
Novel GSK3 Inhibitors for the Treatment of
Neurodegenerative Diseases |
|
12:00 |
Lunch |
|
1:30 PM |
SESSION 13: Symptom Relief: Clinical Data and Novel
Basic Science Approaches |
CHAIR:
Michael J. O´Neill |
|
Martin R. Farlow |
A Review of Basic Science and Clinical Data with
Acetylcholinesterase Inhibitors |
|
2:00 PM |
Michael J. O'Neill |
Ion Channels: a7 Nicotinic Receptors and AMPA
Potentiators as Therapeutic Targets |
|
2:30 PM |
Tim Tully |
Memory Modulation via the CREB Pathway |
|
3:00 PM |
Serghei Bachurin |
Target-Oriented Synthesis of Novel Cognition-Enhancers
in Series of Ionotropic Glutamate Receptors Ligands |
|
7:00 PM |
Farewell Banquet |
