PRELIMINARY PROGRAM

THURSDAY, May 21, 2020
8:30 - 8:45Welcome remarksICMN2020 Organizing Committee
8:45 - 10:25Session I: Glial Contributions to Neurodegeneration Chair: Guojun Bu, PhD
Mayo Clinic FL, USA
8:45 - 9:10 Pathways involving microglia and apoE in neurodegeneration David Holtzman, MD
Washington University School of Medicine in St Louis, USA
9:10 - 9:35 Genomics implicate microglial endolysosomal genes in Alzheimer’s disease risk Alison Goate, PhD
Icahn School of Medicine at Mount Sinai, USA
9:35 - 10:00 Neuroinflammation and microglia from a neuropathological perspectiveJeroen Hoozemans, PhD
VUmc, The Netherlands
10:00 - 10:25 Role of astrocytes in neuronal function and neurodegeneration Hui Zheng, PhD
Baylor College of Medicine, USA
10:25 - 10:45Coffee break
10:45 - 12:25Session II: Genomic and Functional Studies of GliaChair: Robert Vassar, PhD
Northwestern University, USA
10:45 - 11:10Omics analysis of neurodegeneration Bin Zhang, PhD
Icahn School of Medicine at Mount Sinai, USA
11:10 - 11:35 Multiomic landscape and functional analysis of Alzheimer’s disease-associated gene variants in human ESC-derived microgliaHuaxi Xu, PhD
Sanford Burnham Prebys Medical Discovery Institute, USA
11:35 - 12:00Using chimeric models to examine the impact of AD risk genes on human microglial functionMathew Blurton-Jones, PhD
University of California, Irvine, USA
12:00 - 12:25Defective microglial phagocytic function as a determining factor of progression speed in ALSSeung Hyun Kim, MD, PhD
Hanyang University, South Korea
12:25 - 13:45Lunch (with sponsor presentations)
13:45 - 15:25Session III: Novel Systems and Approaches Chair: Riqiang Yan, PhD
University of Connecticut, USA
13:45 - 14:103D models of AD Rudolph Tanzi, PhD
Mass General Hospital/Harvard Med School, USA
14:10 - 14:35 Role of the gut microbiome in modulation of amyloidogenesis and neuroinflammationSangram Sisodia, PhD
University of Chicago, USA
14:35 - 15:00 Influence of obesity and diabetes in ADFrancesca-Fang Liao, PhD
University of Memphis, Tennessee, USA
15:00 - 15:25High-throughput screening to identify novel therapeutic targetsYueming Li, PhD
Sloan Kettering Memorial Cancer Center, USA
15:25 - 15:45Coffee break
15:45 - 17:15 Short Talk I
Six short talks of 15 min each (12 min + 3 min Q&A) to be selected from submitted abstracts
Chair: Henrietta Nielsen, PhD
Roskilde University, Denmark
17:15 - 18:00Panel Discussion I: Glial Contributions to Neurodegeneration
18:15 - 20:00Poster Session 1 and Welcome Reception
FRIDAY, May 22, 2020
8:30 - 10:10Session IV: ApoE and Vascular Contributions to NeurodegenerationChair: Hui Zheng, PhD
Baylor College of Medicine, USA
8:30 - 8:55 Impact of vascular apoE isoforms on brain cognition and Alzheimer-related pathology Guojun Bu, PhD
Mayo Clinic Jacksonville, USA
8:55 - 9:20New insights into the role of peripheral apoE on cerebrovascular functions in Alzheimer’s Disease Cheryl Wellington, PhD
University of British Columbia, Canada
9:20 - 9:45Relevance of a liver APOE4 phenotype and plasma apolipoprotein E levels to pathological processes in the brain Henrietta Nielsen, PhD
Roskilde University, Denmark
9:45 - 10:10The role of angiotensin converting enzyme in Alzheimer’s disease pathogenesis Robert Vassar, PhD
Northwestern University, USA
10:10 - 10:30Coffee break
10:30 - 12:35Session V: Pathogenic Mechanisms of Neurodegeneration (AD and ADRD)Chair: Sangram Sisodia, PhD
Northwestern University, USA
10:30 - 10:55 Circuity dysfunction in AD mouse modelsYouming Lu, MD, PhD
LSU Health, USA
10:55 - 11:20Dystrophic neurites in aging and neurodegenerationRiqiang Yan, PhD
University of Connecticut, USA
11:20 - 11:45 Pathogenic role of abnormal ER-mitochondrial interaction in neurodegenerative diseasesXiongwei Zhu, PhD
Case Western Reserve University, USA
11:45 - 12:10Tau protein & Tau pathology: Structure, aggregation, interaction partners and spreadingEckard Mandelkow, PhD
DZNE, Germany
12:10 - 12:35Cell autonomous and non-cell autonomous functions of BIN1 in Alzheimer’s diseaseGopal Thinakaran, PhD
University of South Florida, USA
12:35 - 14:00Lunch (with sponsor presentations)
14:00 - 15:40Session VI: Pathogenic Mechanisms of Neurodegeneration (PD and ALS)Chair: Gopal Thinakaran, PhD
University of South Florida, USA
14:00 - 14:25 Intracellular pathways of Parkinson’s diseaseDimitri Krainc, MD
Northwestern University, USA
14:25 - 14:50a-Synclein aggregation and toxicityPamela McLean, PhD
Mayo Clinic Jacksonville, USA
14:50 - 15:15 C9Orf72 and ALSLeonard Petrucelli, PhD
Mayo Clinic, USA
15:15 - 15:40 Targeting TDP-43 splicing repression for neurodegenerative diseasePhilip Wong, PhD
Johns Hopkins University, USA
15:40 - 16:00Coffee break
16:00 - 17:30Short Talk II
Six short talks of 15 min each (12 min + 3 min Q&A) to be selected from submitted abstracts
Chair: Hongmei Li, PhD
Mayo Clinic, USA
17:30 - 18:15Panel Discussion II: Vascular Contributions to Neurodegeneration
18:30 - 20:00Poster Session 2
SATURDAY, May 23, 2020
8:30 - 10:10Session VII: Neuropathology and BiomarkersChair: Yueming Li, PhD
Sloan Kettering Memorial Cancer Center, USA
8:30 - 8:55The neuropathological diagnosis of AD and related dementiasDennis Dickson, MD
Mayo Clinic, USA
8:55 - 9:20 BiomarkersColin Masters, MD
Florey Institute
9:20 - 9:45The role of astrocytosis and their interaction with tau pathology in neurodegenerative disorders as studied by molecular imagingAgneta Nordberg, MD, PhD
Karolinska Institute, Sweden
9:45 - 10:10Clinic studies of neurodegeneration TBATBA
10:10 - 10:30Coffee break
10:30 - 12:00Session VIII: Therapeutic InsightsChair: Huaxi Xu, PhD
Sanford Burnham Prebys Medical Discovery Institute, USA
10:30 - 10:55Cell and animal models of tau pathology, modes of toxicity, and therapeutic approachesEva Mandelkow, MD
DZNE, Germany
10:55 - 11:20TREM2 – from target identification to therapeutic modulationChristian Haass, PhD
LMU/DZNE, Germany
11:20 - 11:45NIA perspective on AD/ADRDEliezer Masliah, MD
NIH/NIA, USA
11:45 - 12:00Short talk/poster awards and closing remarks
12:00 - 13:00Lunch and Networking

Confirmed Speakers:

Mathew Blurton-Jones, University of California (USA)
Guojun Bu, Mayo Clinic (USA)
Mark Cookson, National Institute on Aging, National Institutes of Health (USA)
Dennis Dickson, May Clinic (USA)
Alison Goate, Icahn School of Medicine (USA)
Christian Haass, Ludwig-Maximilians University Munich (Germany)
David Holtzman, Washington University School of Medicine in St. Louis (USA)
Jeroen Hoozemans, VU University Medical Center Amsterdam (The Netherlands)
Seung Hyun Kim, Hanyang University College of Medicine (Korea)
Dimitri Krainc, Northwestern University (USA)
Yueming Li, Sloan Kettering Institute (USA)
Eckhard Mandelkow, DZNE (Germany)
Eva-Maria Mandelkow, DZNE (Germany)
Colin Masters, The University of Melbourne (Australia)
Henrietta Nielsen, Roskilde University (Denmark)
Agneta Nordberg, Karolinska Institutet (Sweden)
Leonard Petrucelli, Mayo Clinic FL (USA
Sangram S Sisodia, The University of Chicago (USA)
Rudolph E. Tanzi, Harvard Medical School (USA)
Gopal Thinakaran, The University of Chicago (USA)
Robert Vassar, Northwestern University (USA)
Cheryl Wellington, University of British Columbia (Canada)
Philip Wong, Johns Hopkins University (USA)
Huaxi Xu, Sanford Burnham Prebys Medical Discovery Institute (USA)
Riqiang Yan, University of Connecticut Health (USA)
Bin Zhang, Icahn School of Medicine at Mount Sinai (USA)
Hui Zheng, Baylor College of Medicine (USA)
Xiongwei Zhu, Case Western Reserve University (USA)