PRELIMINARY PROGRAM

THURSDAY, May 21, 2020
8:30 - 8:45Welcome remarksICMN2020 Organizing Committee and the BrightFocus Foundation
8:45 - 10:25Session I: Glial Contributions to Neurodegeneration Chair: Guojun Bu
Mayo Clinic FL, USA
8:45 - 9:10The roles of genes and innate immunity in Alzheimer’s diseaseRudolph Tanzi
Mass General Hospital/Harvard Med School, USA
9:10 - 9:35 Genomics implicate microglial endolysosomal genes in Alzheimer’s disease risk Alison Goate
Icahn School of Medicine at Mount Sinai, USA
9:35 - 10:00Neuroinflammation and microglia from a neuropathological perspectiveJeroen Hoozemans
VUmc, The Netherlands
10:00 - 10:25The role of astrocytosis and their interaction with tau pathology in neurodegenerative disorders as studied by molecular imagingJustin Lee
Institute for Basic Science, Korea
10:25 - 10:45Coffee break/Exhibits
10:45 - 12:25Session II: Functional Studies of GliaChair: Robert Vassar
Northwestern University, USA
10:45 - 11:10 Role of astrocytes in neuronal function and neurodegeneration Hui Zheng
Baylor College of Medicine, USA
11:10 - 11:35 Pathways involving microglia and apoE in neurodegeneration David Holtzman
Washington University School of Medicine in St Louis, USA
11:35 - 12:00 Multiomic landscape and functional analysis of Alzheimer’s disease-associated gene variants in human ESC-derived microgliaHuaxi Xu
Sanford Burnham Prebys Medical Discovery Institute, USA
12:00 - 12:25Defective microglial phagocytic function as a determining factor of progression speed in ALSSeung Hyun Kim
Hanyang University, South Korea
12:25 - 13:45Lunch/Exhibits
13:45 - 15:25Session III: Novel Systems and Approaches Chair: Riqiang Yan
University of Connecticut, USA
13:45 - 14:10Using chimeric models to examine the impact of AD risk genes on human microglial functionMathew Blurton-Jones
University of California, Irvine, USA
14:10 - 14:35Role of the gut microbiome in modulation of amyloidogenesis and neuroinflammationSangram Sisodia
University of Chicago, USA
14:35 - 15:00White matter mechanisms in neurodegenerationFrancesca-Fang Liao
University of Memphis, Tennessee, USA
15:00 - 15:25Mossy cell synaptic degeneration causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer’s diseaseYouming Lu
Tongji Medical School, Huazhong University of Science and Technology, China
15:25 - 15:45Coffee break/Exhibits
15:45 - 17:15Short Talk I
Six short talks of 15 min each (12 min + 3 min Q&A) to be selected from submitted abstracts
Chair: Henrietta Nielsen
Stockholm University, Sweden
17:15 - 18:00Panel Discussion I: Glial Contributions to Neurodegeneration
18:15 - 20:00Poster Session 1 and Welcome Reception
FRIDAY, May 22, 2020
8:30 - 10:10Session IV: ApoE and Vascular Contributions to NeurodegenerationChair: Hui Zheng
Baylor College of Medicine, USA
8:30 - 8:55Impact of vascular apoE isoforms on brain cognition and Alzheimer-related pathology Guojun Bu
Mayo Clinic Jacksonville, USA
8:55 - 9:20New insights into the role of peripheral apoE on cerebrovascular functions in Alzheimer’s Disease Cheryl Wellington
University of British Columbia, Canada
9:20 - 9:45Relevance of a liver APOE4 phenotype and plasma apolipoprotein E levels to pathological processes in the brain Henrietta Nielsen
Stockholm University, Sweden
9:45 - 10:10The role of angiotensin converting enzyme in Alzheimer’s disease pathogenesis Robert Vassar
Northwestern University, USA
10:10 - 10:30Coffee break/Exhibits
10:30 - 12:35Session V: Pathogenic Mechanisms of Neurodegeneration (AD and ADRD)Chair: Sangram Sisodia
Northwestern University, USA
10:30 - 10:55Role of vasculature and glia in the pathogenesis of glaucoma, a leading neurodegenerative diseaseAbbot Clark
University of North Texas Health Science Center, USA
10:55 - 11:20Tau protein & tau pathology: structure, aggregation, interaction partners and spreadingEckard Mandelkow
DZNE, Germany
11:20 - 11:45Pathogenic role of abnormal ER-mitochondrial interaction in neurodegenerative diseasesXiongwei Zhu
Case Western Reserve University, USA
11:45 - 12:10C-terminal CX3CL1 in reversing Alzheimer’s pathology and neurodegenerationRiqiang Yan
University of Connecticut, USA
12:10 - 12:35Cell autonomous and non-cell autonomous functions of BIN1 in Alzheimer’s diseaseGopal Thinakaran
USF Morsani College of Medicine, USA
12:35 - 14:00Lunch/Exhibits
14:00 - 15:40Session VI: Pathogenic Mechanisms of Neurodegeneration (PD and ALS)Chair: Gopal Thinakaran
USF Morsani College of Medicine, USA
14:00 - 14:25Multiscale gene network analysis identifies novel pathways and key regulators of Parkinson’s diseaseBin Zhang
Icahn School of Medicine at Mount Sinai, USA
14:25 - 14:50 Mitochondrial and lysosomal dysfunction in Parkinson's disease: therapeutic implications in human neuronsDimitri Krainc
Northwestern University, USA
14:50 - 15:15 Understanding the mechanistic link between C9orf72 and TDP-43Leonard Petrucelli
Mayo Clinic, USA
15:15 - 15:40Targeting TDP-43 splicing repression for neurodegenerative diseasePhilip Wong
Johns Hopkins University, USA
15:40 - 16:00Coffee break/Exhibits
16:00 - 17:30Short Talk II
Six short talks of 15 min each (12 min + 3 min Q&A) to be selected from submitted abstracts
17:30 - 18:15Panel Discussion II: Vascular Contributions to Neurodegeneration
18:15 - 20:00Poster Session 2
SATURDAY, May 23, 2020
8:30 - 10:10Session VII: Neuropathology and Clinical InsightsChair: TBA
8:30 - 8:55Molecular origins of Alzheimer’s disease: when does it start, and how long does it take?Colin Masters
Florey Institute, Australia
8:55 - 9:20The neuropathological diagnosis of AD and related dementiasDennis Dickson
Mayo Clinic, USA
9:20 - 9:45Targeting Aβ protofibrils with BAN2401 - from mutation to potential therapy for ADLars Lannfelt
Uppsala University, Sweden
9:45 - 10:05Coffee break/Exhibits
10:05 - 12:00Session VIII: Therapeutic ApproachesChair: Huaxi Xu
Sanford Burnham Prebys Medical Discovery Institute, USA
10:05 - 10:30Cell and animal models of tau pathology, modes of toxicity, and therapeutic approachesEva Mandelkow
DZNE, Germany
10:30 - 10:55TREM2 – from target identification to therapeutic modulationChristian Haass
LMU/DZNE, Germany
10:55 - 11:20Therapeutic strategies targeting alpha-synuclein in AD-related dementiaPamela McLean
Mayo Clinic, USA
11:20 - 11:45BrightFocus Foundation Travel Fellowship Award Ceremony Diane Bovenkamp and Keith Whitaker
BrightFocus Foundation, USA
11:45 - 12:00Short talk/poster awards and closing remarks
12:00 - 13:00Lunch and Networking

Confirmed Speakers:

Mathew Blurton-Jones, University of California (USA)
Guojun Bu, Mayo Clinic (USA)
Abbot Clark, University of North Texas Health Science Center (USA)
Dennis Dickson, May Clinic (USA)
Francesca-Fang Liao, University of Memphis, Tennessee (USA)
Alison Goate, Icahn School of Medicine (USA)
Christian Haass, Ludwig-Maximilians University Munich (Germany)
David Holtzman, Washington University School of Medicine in St. Louis (USA)
Jeroen Hoozemans, VU University Medical Center Amsterdam (The Netherlands)
Seung Hyun Kim, Hanyang University College of Medicine (Korea)
Dimitri Krainc, Northwestern University (USA)
Lars Lannfelt, Uppsala University (Sweden)
Justin Lee, Institute for Basic Science (Korea)
Youming Lu, Tongji Medical School, Huazhong University of Science and Technology (China)

Eckhard Mandelkow, DZNE (Germany)
Eva-Maria Mandelkow, DZNE (Germany)Colin Masters, The University of Melbourne (Australia)
Pamela McLean, Mayo Clinic (USA)
Henrietta Nielsen, Stockholm University (Sweden)
Leonard Petrucelli, Mayo Clinic FL (USA)
Sangram Sisodia, The University of Chicago (USA)
Rudolph Tanzi, Harvard Medical School (USA)
Gopal Thinakaran, USF Morsani College of Medicine (USA)
Robert Vassar, Northwestern University (USA)
Cheryl Wellington, University of British Columbia (Canada)
Philip Wong, Johns Hopkins University (USA)
Huaxi Xu, Sanford Burnham Prebys Medical Discovery Institute (USA)
Riqiang Yan, University of Connecticut Health (USA)
Bin Zhang, Icahn School of Medicine at Mount Sinai (USA)
Hui Zheng, Baylor College of Medicine (USA)
Xiongwei Zhu, Case Western Reserve University (USA)